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Toxic Granulation

Toxic granulations are darker-coloured granules that can be seen under a microscope in neutrophils, the most abundant class of white blood cells. These granules are often larger and more abundant than normal granules. Their presence is non-specific and usually signals a bacterial infection or inflammation. They can also be observed in late-pregnancy, when the bone marrow is recovering after chemotherapy or after treatment with drugs (Neupogen©, Neulasta©, Grastofil©) that stimulate the formation of granulocytes (neutrophils) by the bone marrow.

Term of the Week

Hot zone

A hot zone is a section of a facility (sometimes an entire facility or even a city district) where there is a high risk of contamination by patients with an infectious disease. All individuals entering a hot zone must respect appropriate protective measures. By analogy, “cold zone” and “warm zone” are used to refer to areas where there is no infected individual or only individuals suspected of having an infection.