The anti-Müllerian hormone or AMH is a hormone produced by the reproductive tissues (testicles and ovaries). It plays a role in the development and maturation of follicles (ovulation) in women. AMH secretion begins a few days before birth, peaks at puberty and then decreases with age until menopause, when it becomes undetectable. AMH is considered a reliable indicator of ovarian reserve (oocyte stock), very useful information in clinics to assess fertility potential and stimulation risks.
Results are expressed in picomoles of AMH per litre of serum (pmol/L). Results must be interpreted in light of other available clinical and imaging information (ultrasound) and the results of other fertility-related hormones and indicators such as FSH, LH, estradiol, inhibin B, etc.
In the context of in vitro fertility, levels of AMH between 7.0 and 20 pmol/L are predictive of a normal response to ovarian stimulation. Rates below 1.1 pmol/L are predictive of an extremely low response, while rates between 1.1 and 6.9 pmol/L are predictive of a reduced response. Rates above 20 pmol/L may be associated with a potentially excessive response and minimal stimulation may be indicated.