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Antideoxyribonuclease-B, ADN B

Anti-DNase B

Anti-DNase B (antideoxyribonuclease-B, ADN B) and ASO are the main antibodies produced by the body in response to a group A beta-hemolytic streptococcus infection (strep A). This bacteria is responsible for many throat infections, impetigo and cellulitis and usually responds well to antibiotic treatment. If a strep A infection is not diagnosed or is poorly treated, it can lead to complications such as acute rheumatism (rheumatic fever) or glomerulonephritis (kidney inflammation). However, a small percentage of people who develop complications and have low ASO levels may have high levels of anti-DNase B. This is especially the case when the glomerulonephritis is linked to a strep A skin infection.

A negative or very low result, especially if repeated 10 to 14 days later, indicates that the person probably did not have a recent strep A infection, but there are rare exceptions. If the concentration is high or increasing, a recent strep A infection is very likely. The anti-DNase B blood test cannot be used to predict whether complications will occur or to predict the type and severity of the disease. If symptoms of rheumatic fever or glomerulonephritis are present, a high anti-DNase B titre will help confirm the diagnosis.

Term of the Week

Hot zone

A hot zone is a section of a facility (sometimes an entire facility or even a city district) where there is a high risk of contamination by patients with an infectious disease. All individuals entering a hot zone must respect appropriate protective measures. By analogy, “cold zone” and “warm zone” are used to refer to areas where there is no infected individual or only individuals suspected of having an infection.