Skip to contentSkip to navigation


Anti-CCP antibodies are antibodies that appear specifically in rheumatoid arthritis (RA). There are several dozen forms of joint inflammation (arthritis). In addition to autoimmune forms such as RA and lupus, there are cases of arthritis due to aging (normal “wear and tear”), gout, fractures or infections (viral, bacterial or fungal). The presence of anti-CCP antibodies helps to confirm the presence of RA among these different causes, establish a prognosis with respect to disease progression, and choose the best possible treatment. Anti-CCP test results are interpreted by a hematologist.

When anti-CCP and RA tests are negative, the arthritis is most likely due to a cause other than RA. In individuals with signs and symptoms of arthritis, positive anti-CCP and RA test results strongly suggest RA, and affected individuals could develop the more progressive and severe form of the disease.

When the anti-CCP test is positive but the RA test is negative or slightly positive, it is probably the early stage of the disease. When the anti-CCP test is negative but the RA test is positive, other clinical data will determine the nature of the arthritis.

Term of the Week

Hot zone

A hot zone is a section of a facility (sometimes an entire facility or even a city district) where there is a high risk of contamination by patients with an infectious disease. All individuals entering a hot zone must respect appropriate protective measures. By analogy, “cold zone” and “warm zone” are used to refer to areas where there is no infected individual or only individuals suspected of having an infection.