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Howell-Jolly Body

Howell-Jolly bodies are the nuclear remnants that can be found in red blood cells before their final maturation. These nuclear remnants are normally eliminated by the spleen. Howell-Jolly bodies are found in patients with no spleen (surgical splenectomy) or a spleen that does not function well (hyposplenism). They are also found in some red blood cell maturation disorders.

Term of the Week

Creatine Kinase MM (CK-MM)

CK (creatine kinase) is an enzyme (protein) found in several tissues, including muscles and the heart. Depending on the tissue, different forms of CK are present: CK-MM is primarily present in skeletal muscles, CK-MB represents 30% of CK from the heart, while CK-BB comes from the brain and smooth muscle, such as the intestinal walls. Atypical forms of CK (macro CK1 and macro CK2) can also be present. CK electrophoresis is most useful when muscular or cardiac disease does not seem to be responsible for the increased level of total CK.