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Specialist Advice — 12 minutes

Nocturnal asthma, the enemy of sleep

Sleep care team
Sleep care team
info@biron.com

Asthma is characterized by inflammation and narrowing of the airways, which makes breathing difficult. The symptoms are often more intense at night, producing what is known as “nocturnal asthma.” Although the mechanisms behind this exacerbation are not fully understood, certain habits can help improve sleep quality.

A common phenomenon in asthmatics

Up to 75% of asthmatics reportedly have more intense symptoms at night.[1] Wheezing, coughing, tightness and shortness of breath can wake them up many times and disrupt their sleep. One study found that more than a quarter of adults with asthma sleep less than five hours a night.[2]

Lack of sleep also affects their quality of life during the day. Asthmatics who experience nighttime symptoms are at risk of the following:

  • lack of concentration
  • daytime sleepiness
  • difficulty controlling asthma during the day
  • more frequent hospitalizations
  • poor overall health[2]

Insomnia triples the risk of becoming asthmatic

Because it disturbs sleep, asthma can be a cause of insomnia. But the reverse is also true: this sleep disorder is believed to influence the development of asthma. In 2017, Norwegian researchers showed that people who reported chronic insomnia were three times more likely to develop asthma.[3] Insomnia is thought to promote the production of inflammatory cytokines, which in turn cause airway inflammation.

Factors that disturb nights

While nocturnal asthma can have the same triggers as asthma, such as a cold, dust, tobacco smoke and temperature, some factors can increase symptoms at night.

Bodily functions

During sleep, the airways narrow, and the muscles relax, both natural phenomena. In asthmatics, airway narrowing, which is already a problem, can amplify asthma symptoms. At the same time, decreased muscle tone during the night can lead to shallow breathing and a decrease in the amount of air inhaled.

Circadian rhythm

The autonomic nervous system, on which lung function depends, many sleep-related hormones and even the inflammatory mechanism are circadian, meaning that their activity varies according to a 24-hour cycle linked to the body’s internal clock. Changes that occur in the evening and at night can, for example, reduce the depth and rate of breathing, reduce lung function, or stimulate airway inflammation, which increases the risk of nocturnal asthma.[4]

Obesity

Excess fat around the throat and increased systemic inflammation due to obesity may increase nocturnal asthma. Studies have shown that weight loss improves lung function and reduces nocturnal symptoms.[5]

Gastroesophageal reflux disease (GERD)

Between 33 and 89% of people with asthma have symptoms of GERD.[6] Although no causal link has been established between the two conditions, it is thought that the reflux of gastric acid into the esophagus could trigger bronchial spasms or airway constriction leading to nighttime asthma symptoms. The reflux could also enter the lungs, irritating the airways.

Obstructive sleep apnea (OSA)

OSA has also been identified as a risk factor for nocturnal asthma.[7] In patients with asthma, the snoring characteristic of apnea triggers neural reflexes that cause bronchial constriction, exacerbating asthma. In addition, repeated breathing interruptions during sleep deprive the body of oxygen and increase the reactivity of the bronchi and airways.

Which sleeping position should I adopt?

Is there a miracle position that will eliminate all symptoms of nocturnal asthma? Unfortunately, no. The ideal position depends on the individual and the severity of asthma. It would be best to experiment with different sleeping ways to see what works.

On your back

The supine position can put pressure on the chest and lungs, making breathing difficult and triggering mucus to flow down the throat. It can also promote gastroesophageal reflux. Therefore, it is best to elevate the neck and shoulders with one or more pillows. This helps keep the airways open, circulate mucus and prevent acid reflux. Adding another pillow under the knees helps improve circulation and maintain this elevated position throughout the night.

On your side

People with asthma who sleep on their side, especially those with gastroesophageal reflux disease, should prefer the left side, elevating the head with a pillow. The right-side position increases pressure on the vagus nerve, which causes airway constriction. Adding a pillow between the legs stabilizes the spine and helps maintain a better sleeping position.

On your front

Lying on your front is not recommended as it causes back and neck strain, compresses the rib cage, and impairs breathing. People who cannot do otherwise should consider leaving their pillow aside (or using a very flat pillow) and placing a cushion under the pelvis to prevent the back from sagging.

Prevention for a better night’s sleep

One way to reduce nighttime symptoms is to control your asthma by following the treatment recommended by your doctor. Eliminating triggers in the bedroom can also help. Here are some tips to improve your environment:

  • Eliminate dust mites and dust by washing bedding, vacuuming and dusting furniture regularly. Using allergy-friendly pillows and mattress covers can also help.
  • Keep pets out of the bedroom.
  • Make the room a scent and fragrance-free zone by eliminating strong-smelling products such as cleaners, candles and personal care products.
  • Relax before bed, as stress is a common trigger. Relaxing activities, such as listening to soft music, taking a warm bath or reading, can help you fall asleep faster and reduce stress-related asthma attacks.
  • Close windows to avoid temperature changes, pollen and pollution.
  • Use a dehumidifier or air conditioner to keep the relative humidity between 40 and 50%.

By controlling your asthma with appropriate medications, reconsidering your sleeping habits and controlling environmental factors, you can find a way to reduce your nocturnal asthma symptoms and improve the quality of your sleep.

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Sources7
  1. Pinyochotiwong, C., N. Chirakalwasan and N. Collop. “Nocturnal Asthma”, Asian Pacific Journal of Allergy and Immunology, vol. 39, no. 2, June 2021, p. 78-88, https://apjai-journal.org/wp-content/uploads/2021/07/6_AP-231020-0986-1.pdf
  2. Luister, F. S., X. Shi, L. M. Baniak, J. L. Morris and E. R. Chasens. “Associations of sleep duration with patient-reported outcomes and health care use in US adults with asthma”, Annals of Allergy, Asthma & Immunology, vol. 125, no. 3, p. 319-324, 2020, https://www.sciencedirect.com/science/article/abs/pii/S1081120620303161
  3. Brumpton, B., X.-M. Mai, A. Langhammer, L. E. Laugsand, I. Janszky and L. B. Strand. “Prospective study of insomnia and incident asthma in adults: the HUNT study”, European Respiratory Journal, vol. 49, no. 2, 2017, https://erj.ersjournals.com/content/49/2/1601327
  4. Scheer, F., M.F. Hilton, H. L. Evoniuk, S. A. Shea et al. “The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles”, PNAS, vol. 38, no. 7, 2021, https://www.pnas.org/doi/10.1073/pnas.2018486118
  5. Trunk-Black Juel, C. Juel, Z. Ali, L. Nilas and C. Suppli Ulrik. “Asthma and obesity: does weight loss improve asthma control? A systematic review”, Journal of Asthma and Allergy, vol. 5, p. 21-26, 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392696/
  6. Bouchentouf, R. “Pathologies respiratoires liées au reflux gastro-œsophagien”, Journal of Functional Ventilation and Pneumology, vol. 3, no. 6, p. 4-7, 2012, https://www.jfvpulm.com/librarys/uploads/070346-REVIEW1-N6-FR.pdf
  7. Ten Brinke, A., P. J. Sterk, A. A. M. Masclee, P. Spinhoven, J. T. Schmidt, A. H. Zwinderman, K. F. Rabe and E. H. Bel. “Risk factors of frequent exacerbations in difficult-to-treat asthma”, European Respiratory Journal, vol. 26, no. 5, p. 812-818, 2005, https://erj.ersjournals.com/content/26/5/812
Sleep care team
Sleep care team
info@biron.com