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Specialist Advice — 9 minutes

Let’s demystify three types of vaginitis

February 16, 2024

Raymond Lepage, PhD, Doctor in Biochemistry
Raymond Lepage, PhD, Doctor in Biochemistry
Science popularizer

Vaginitis is common. It is estimated that 75% of women will experience at least one bout of vaginitis in their lifetime, and around half will have several [1]. This inflammation of the vaginal wall is characterized by an abnormal and sometimes odorous vaginal discharge, irritation, itching (pruritus) and redness (erythema) of the vaginal wall.

These unpleasant effects are generally temporary, but if left untreated, they can lead to more severe consequences, such as co-infections (including STBBIs such as HIV), pregnancy complications, premature delivery, infertility, etc.

What are the different types of vaginitis?

The vagina hosts an abundance of bacterial flora, more than 90% of which are lactobacilli. These bacteria are beneficial, as the lactic acid they produce maintains the vagina’s acidic pH and prevents infection by other undesirable bacteria. Problems arise when this balance is upset, and the lactobacilli no longer protect against the pathogenic microbes that can cause infection. Vaginitis is infectious in 70-90% of cases, but can be non-infectious 10-30% of the time [2].

Infectious vaginitis

  • Bacterial vaginosis: 40 to 50% of cases
  • Yeast vaginitis (candidiasis): 20 to 25% of cases
  • Parasitic vaginitis (trichomoniasis): 15 to 20% of cases

Non-infectious vaginitis

  • Irritant vaginitis: Can be caused by antibiotics, a foreign body (tampon or condom), soaps or other vaginal hygiene products, poor personal hygiene, dermatosis, systemic inflammatory diseases such as rheumatoid arthritis or lupus, etc.
  • Atrophic vaginitis: Occurs in post-menopausal women or those with low estrogen levels. Low estrogen levels lead to dryness and thinning of the vaginal wall, which becomes more easily irritated.

What are the risk factors for infectious vaginitis?

Bacterial vaginosis

Vaginosis, which is sometimes asymptomatic, is a change in the composition of the vaginal flora, with a decrease in lactobacilli and an increase in other types of bacteria. Although bacterial vaginosis is not considered an STBBI, it shares the same risk factors (see “Parasitic vaginosis” below). However, this infection also occurs in women who have never had sexual intercourse with vaginal penetration.

Yeast vaginitis (candidiasis)

Characterized by the proliferation of the fungus Candida albicans, candidiasis often occurs for no apparent reason. However, it occurs more frequently in the following women:

  • Pregnant (higher estrogen levels)
  • Diabetic
  • Immunosuppressed
  • Treated with antibiotics

Antibiotics tend to upset the balance of vaginal flora and vaginal pH, encouraging yeast to multiply. As a result, a third to a quarter of women develop candidiasis during or after taking antibiotics.

Parasitic vaginitis (trichomoniasis)

Caused by the parasite trichomonas vaginalis, trichomoniasis is considered a non-viral STBBI. Therefore, its risk factors are the same as for other common STBBIs:

  • Multiple sex partners
  • History of STBBIs
  • One or more previous episodes of trichomoniasis
  • Unprotected sex

Vaginitis can also be caused by a sexually transmitted and blood-borne infection (STBBI), such as gonorrhea or chlamydia.

How is vaginitis diagnosed?

The appearance of a vaginal discharge and the presence of other symptoms can indicate to the healthcare professional the likely nature of vaginitis and, in the case of candidiasis, enable the affected person to obtain over-the-counter medication. However, to confirm the diagnosis, the healthcare professional will need to carry out laboratory tests.

Appearance of discharge Other symptoms Possible diagnosis
Reddish or brownish Abnormal bleeding, pelvic pain Irregular menstrual cycles, very rarely cervical or endometrial cancer
Cloudy or yellowish Bleeding between periods, urinary incontinence, pelvic pain Gonorrhea
Foamy, yellowish or greenish, malodorous Pain when urinating, itching Parasitic vaginitis (trichomoniasis)
Pinkish Uterine wall erosion after childbirth
Thick, whitish, lumpy Redness and swelling of the vulva and vagina, pain, itching, painful intercourse Yeast vaginitis (candidiasis)
Homogeneous, milky texture, whitish, greyish, yellow-green, fishy odour Itching and burning, redness, swelling of the vagina and vulva, especially in cases of co-infection. Nearly half of affected women have no symptoms. Bacterial vaginosis

How is infectious vaginitis treated?

Treatment of vaginitis depends on the cause of the infection [3].

Bacterial vaginosis

Oral or topical antibiotic treatment is preferred in non-pregnant women. In pregnant women, oral treatment is recommended to avoid complications. Screening for vaginosis during pregnancy can be carried out for certain at-risk women, but is not immediately recommended. However, bacterial vaginosis with symptoms during pregnancy should be treated to avoid pregnancy complications.

Depending on the situation, the medications recommended are metronidazole 500 mg orally for five to seven days, metronidazole gel or clindamycin intravaginal cream. A single oral dose of metronidazole is also possible, but the cure rate is 85%, with a higher recurrence rate of 30-50% at one month.

Yeast vaginitis

Simple yeast vaginitis is treated with antifungal agents such as oral fluconazole and topical clotrimazole. In pregnant women, topical treatment with clotrimazole is recommended, but a doctor should confirm the diagnosis before treatment.

If you suffer from yeast vaginitis, you can obtain clotrimazole over the counter in pharmacies or consult a pharmacist, who can prescribe fluconazole. Symptoms generally improve within two to three days after starting treatment.

Parasitic vaginitis (trichomoniasis)

Trichomoniasis requires an effective oral antibiotic to eliminate the parasite. Treatment may take the form of a single massive dose of 2 g of metronidazole, or lower doses of metronidazole for seven days. As with any antibiotic, metronidazole must be taken until the end of the prescribed period.

To avoid recurrence, it is important that all sexual partners of the infected person be treated at the same time. These people should also discontinue sexual relations until symptoms have completely disappeared and the treatment is finished.

What are the possible complications of infectious vaginitis?

Bacterial vaginosis

Bacterial vaginosis increases the risk of contracting or spreading a concomitant STBBI. Adverse effects occur mainly during pregnancy, with an increased risk of amniotic fluid infection, premature labour and delivery, and post-delivery or post-abortion infections.

Yeast vaginitis

Complications of yeast vaginitis are rare. Recurrence of the infection and its unpleasant symptoms is the most common. Pregnant patients can also infect the fetus, which can lead to systemic infections in the newborn, particularly if it is premature or has low birth weight [4].

Parasitic vaginitis (trichomoniasis)

In addition to being contagious, trichomoniasis increases the risk of contracting other STBBIs, including HIV. It can also lead to the development of pelvic inflammatory disease (infection of the uterus and fallopian tubes) or infertility. Pregnant women are more likely to give birth prematurely and have a low-birth-weight baby [5].

How to prevent infectious vaginitis?

Bacterial vaginosis

  • Avoid douches and other vaginal hygiene products, such as sprays, scented soaps and deodorant pads and tampons.
  • When using the toilet, always wipe from front to back (vagina to anus).
  • Wear cotton or cotton-covered underwear.
  • Change tampons or sanitary pads frequently.
  • Protect yourself during sexual relations (condom or dental dam) and limit the number of partners.

Yeast vaginitis

  • Limit the use of vaginal hygiene products such as scented soaps, gels, creams, etc.
  • Identify, with the help of your pharmacist, any treatments that may increase the risk of candidiasis (antibiotics, cortisone, certain oral contraceptives, chemotherapy).
  • Avoid wearing wet bathing suits or tight-fitting, synthetic clothing for too long. Choose loose-fitting cotton clothing.
  • Use a personal lubricant, avoiding overly scented and irritant products.
  • Control diabetes and avoid a high-sugar diet.
  • Avoid stress and other conditions that weaken the immune system.

Parasitic vaginitis

As trichomoniasis is an STBBI, precautions are the same as for other STBBIs. These include avoiding or limiting sexual relations and protecting yourself. Here are a few ways of protecting yourself and your partner against trichomonas vaginalis infection:

  • Use a condom during vaginal or anal intercourse.
  • Use a polyurethane condom or dental dam.
  • Avoid sharing sex toys or cover them with a new condom before use.
Sources5
  1. Clinique médicale l’Actuel. “La vaginite est-elle fréquente?” https://cliniquelactuel.com/La_vaginite_est_elle_frequente [accessed on February 8, 2024].
  2. Sobel, Jack D. “Vaginitis in adults: Initial evaluation,” UpToDate, https://www.uptodate.com/contents/vaginitis-in-adults-initial-evaluation [accessed on February 8, 2024].
  3. INESS. “Protocole médical national – Pertes vaginales inhabituelles,” Institut national d’excellence en santé et en services sociaux, June 2019, https://www.inesss.qc.ca/fileadmin/doc/INESSS/Ordonnances_collectives/Vaginite/INESSS_Protocole_medical_national_pertes-vaginales-inhabituelles_Final.pdf.
  4. Arya, N.R., Naureen, B. “Candidiasis,” StatPearls, May 29, 2023, https://www.ncbi.nlm.nih.gov/books/NBK560624/.
  5. New York State Department of Health. “Trichomoniasis. A common curable STD,” https://www.health.ny.gov/publications/3839.pdf [accessed on February 8, 2024].
Raymond Lepage, PhD, Doctor in Biochemistry
Raymond Lepage, PhD, Doctor in Biochemistry
Science popularizer
For about 50 years, Raymond Lepage worked as a clinical biochemist in charge of public and private laboratories. An associate clinical professor at the Faculty of Medicine of the Université de Montréal and an associate professor at the Université de Sherbrooke, he has also been a consultant, researcher, legal expert and conference speaker. He has authored or co-authored more than 100 publications for scientific conferences and journals, and now devotes part of his semi-retirement to popularizing science.