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Managing anxiety: exploration of treatment options

May 6, 2024

Michel Cameron, PhD
Michel Cameron, PhD
Associate Director, Pharmacogenomics, Medical Science Liaison
LinkedIn

Anxiety, or generalized anxiety disorder (GAD), is a prevalent mental health condition that affects more than 15% of Canadians [1]. GAD can have a significant impact on an individual’s quality of life in various areas, notably on physical health, mental wellness, social relationships and overall functioning.

Main impacts of anxiety

Physical health: People struggling with GAD can suffer from a variety of physical symptoms, including muscle tension, fatigue, headache, gastrointestinal problems and sleep disorders. In addition, the chronic worry and stress associated with GAD can weaken a person’s immune system, making them more susceptible to illness and exacerbating existing health issues. Lastly, a constant state of hyperactivity can also lead to cardiovascular problems.

Mental wellness: Persistent and excessive worrying is a characteristic of GAD that can cause chronic stress and put pressure on mental health. People with GAD may experience high levels of anxiety and irritability, as well as difficulty concentrating, which can alter cognitive function and decision-making ability. In addition, GAD is often associated with other mental health disorders such as depression, which exacerbates psychological distress.

Social relationships: The endless worrying, anxiety and fear characteristic of GAD can strain personal relationships. The constant need for reassurance and the avoidance of anxiety-inducing situations can cause conflicts with family members, friends and co-workers. Social withdrawal and isolation are common coping mechanisms among people with GAD, limiting their ability to maintain significant connections with others and take part in social activities.

Occupational functioning: GAD can have a significant impact on occupational or academic functioning. Difficulty concentrating, making decisions and meeting deadlines can affect academic performance. Persistent apprehension and anticipation of negative results can lead to procrastination, absenteeism and reduced productivity. In serious cases, GAD can even interfere with a person’s ability to pursue their occupational or educational goals.

Quality of life: The cumulative impact of physical symptoms, psychological distress, altered social functioning and occupational challenges can adversely affect the overall quality of life of people struggling with GAD. Feelings of powerlessness, despair and frustration can have a negative impact on a person’s sense of satisfaction and personal fulfillment. Activities that were once enjoyable can lose their appeal when anxiety takes over, leading to a sense of disconnection and discontent.

Pharmacological interventions

Medications, such as antidepressants, are commonly used to treat anxiety disorders. These medications work by regulating the neurotransmitters in the brain, which helps reduce feelings of fear and anxiety. Another class of medications, benzodiazepines, provide rapid relief of acute anxiety, but their use is generally limited to the short term given the risk of dependency and tolerance.

Traditionally, the choice of medication for treating anxiety was based on trial and error, which could result in prolonged suffering and frustration for the patient. However, with pharmacogenomic testing, health care providers can now make more informed decisions and adapt treatment plans to the individual’s genetic profile [2]. This approach not only improves the efficacy of the treatment, but also minimizes the risk of unwanted side effects.

For people suffering from severe anxiety and for those resistant to treatment, pharmacological interventions can be essential in effectively managing symptoms. However, medications alone are not always sufficient for treating the underlying causes of anxiety or providing long-term solutions.

Non-pharmacological approaches

Therapy: Therapy, in particular cognitive behavioural therapy (CBT), exposure therapy and mindfulness therapy, has proven effective in the treatment of anxiety disorders. These approaches help individuals identify and reconsider negative thought patterns, develop coping strategies and gradually face feared situations, thereby fostering resilience and empowerment.

Changes in lifestyle: Adopting healthy lifestyle habits can play a significant role in reducing anxiety symptoms. Regular exercise, sufficient sleep, a balanced diet and stress management techniques such as deep breathing and meditation foster general wellness and strengthen resilience to stress.

Mind, body and spirit practices: Yoga and tai chi combine physical postures, breathing techniques and meditation to promote relaxation and reduce stress. These mind, body and spirit practices not only relieve physical tension, but also foster mindfulness and self-awareness, allowing individuals to manage their anxiety more effectively.

Social support: Developing a strong support network of family and friends or joining a support group can provide invaluable emotional support and tangible assistance in managing anxiety. Connecting with others who understand and are empathetic to your experiences can reduce feelings of isolation and create a sense of belonging and acceptance.

Combination of pharmacological and non-pharmacological approaches

In many cases, a combination of pharmacological and non-pharmacological interventions can provide the best results when it comes to managing anxiety. By addressing both the physiological and psychological aspects of anxiety, people benefit from a holistic approach and treatment adapted to their needs and preferences.

In conclusion, managing anxiety requires a multifaceted approach that goes beyond medication alone. Although pharmacological interventions may be necessary for some people, non-pharmacological approaches offer invaluable opportunities or complementary strategies for promoting mental health and wellness. By exploring various treatment options and cooperating with health care providers, an individual can develop personalized strategies to better manage their anxiety and regain control of their life.

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Sources2
  1. Statistics Canada. Survey on COVID-19 and Mental Health (5330).
  2. Bousman et al. Clin Pharmacol Ther (2023) 114(1):51-68.
Michel Cameron, PhD
Michel Cameron, PhD
Associate Director, Pharmacogenomics, Medical Science Liaison
LinkedIn
Seeking to make the science of genetics accessible for everyone, in 2014 Michel Cameron co-founded BiogeniQ, a company specialized in genetics, where he directed the design and development of pharmacogenomics tests. Today this company is owned by Biron. Michel Cameron holds a Ph.D. in pharmacology from the Université de Montréal and completed postdoctoral studies in pharmacogenomics at the Montreal Heart Institute’s Pharmacogenomics Centre.