Cardiovascular and metabolic health: five silent signs to watch for
September 18, 2025

Do you often experience fatigue or shortness of breath with the slightest effort? Are you always thirsty? Have you noticed that your waist isn’t getting any smaller even though your weight is stable? There may be several causes for these symptoms, but they are often related to cardiovascular or metabolic disease, or a combination of both—known as cardiometabolic disease.
Why focus on this kind of disease? Firstly, because it is very common: in Canada, more than 8 in 10 people have at least one risk factor for cardiovascular disease (CVD). [1] As well, even though it does cause many early deaths, CVD can be largely controlled with good lifestyle habits. [2] Lastly, you can often access testing quickly, even without an immediate consult with a healthcare provider.
Knowing the risks and effects
Cardiovascular and metabolic disease includes illnesses such as high blood pressure, diabetes and high levels of “bad cholesterol” (hypercholesterolemia). These can lead to serious complications like heart attack, stroke, heart failure, kidney failure—which may require dialysis—, liver disease and some kinds of cancer. [3]
These common conditions often have severe, sometimes fatal, outcomes. CVD is the second cause of death in Canada, with cerebrovascular disease (e.g., stroke) in fifth place and type 2 diabetes in ninth. [4] These illnesses also have non-fatal effects which may still be very debilitating, such as kidney failure. Even a non-fatal stroke can sometimes have very severe outcomes, not to mention amputations or blindness due to poorly controlled diabetes, a limp caused by blocked arteries, cirrhosis of the liver due to fat accumulation (steatosis) in the liver, and more.
Understanding your risks
Identifying your own risk factors is an essential first step for taking control of your health.
CVD risk factors can be divided into two categories: uncontrollable risks (age, sex, hereditary family history) and controllable risks (poor lifestyle habits such as smoking, alcohol use, unbalanced diet or being inactive).
As their name implies, there’s nothing we can do about uncontrollable risks, but that is no reason to ignore them. To a large extent, the harmful effects of these illnesses can be controlled by medication, but it is particularly important to do something about the controllable risk factors which add to the harmful effects, making them worse. These factors are easy to identify, even though some firmly rooted habits may be hard to change.
When to pay attention
Because cardiovascular and metabolic disease is so widespread, it is important that you don’t ignore certain symptoms:
There can be many causes for fatigue, such as medications, stress, depression or hormonal (endocrine) disorders. The impact of chronic fatigue is well known and includes finding it hard to concentrate, low energy for usual activities, irritability, drowsiness and headache. Fatigue is also common in people with high blood pressure, CVD and diabetes, although the connection with unexplained fatigue is not always obvious.
Sudden shortness of breath after walking for a few minutes or going up a few steps is not normal for a healthy person. It may be caused by heart failure or another heart condition, lung problems, anemia, inactivity or another physical problem.
Shortness of breath is a common symptom of cardiovascular disease, particularly in the presence of cardiac overload, poor circulation associated with high blood pressure or a cholesterol-related problem.
Some common conditions such as stress and too much coffee and alcohol may increase how often you need to pee (polyuria). In women, urinary tract infections, and in men, an enlarged prostate (benign prostatic hyperplasia or BPH), are also common causes of polyuria.
However, polyuria plus intense thirst (polydipsia) is often a sign of excess sugar in the blood, the very definition of diabetes. Polydipsia and polyuria are often the first, or only, symptoms of type 2 diabetes.
It seems like it’s always easier to lose weight from your face or arms and legs than around your waist. And yet, surplus fat around the abdomen—meaning a waistline more than 94 cm for men and 80 cm for women—is a key indicator of being overweight or obese. This factor is part of metabolic syndrome, closely linked to a higher risk of chronic disease and death. [5]
When cholesterol shows up
Symptoms of high cholesterol are not always as easy to identify as the symptoms of other forms of cardiovascular or metabolic disease, but two types of symptoms may reveal a problem:
In people with the highest cholesterol levels—familial hypercholesterolemia—, you can see yellowish deposits around the eyes, called xanthelasma, or deposits under the skin, called xanthoma. In seniors, grey rings around the cornea (corneal arcus or arcus senilis) may also appear. [6]
Another long-term effect of having too-high cholesterol is peripheral artery disease. PAD is caused by deposits of cholesterol plaque on artery walls—atherosclerosis—which reduce blood flow, limit ability to walk, cause leg pain (even at rest), and are responsible for sores on the toes and heels which take a long time to heal. [7]
Symptoms in your legs should not be taken lightly: if peripheral arteries in the legs are partially blocked by cholesterol plaques, other arteries probably are as well, increasing the potential risks of heart attack or stroke.
Controlling your health easily
Taking care of your health means first listening to your body and integrating small habits which make a big difference every day—moving regularly, having a balanced diet, sleeping well and taking time to relax.
When it becomes necessary to do more to prevent cardiovascular or metabolic problems, cardiometabolic screening offers an overview of your key indicators: blood sugar and cholesterol levels, blood pressure, weight and waistline. They help identify your risk factors and confirm your status, so you can make informed decisions before any complications arise.
For professional support, we’re here.
We provide a no-prescription, accessible service to help you access tests and healthcare providers faster.
For any questions or more information about this service, contact our team at 1 855 657-5458.
Sources7
- Heart&Stroke. “Fighting for Prevention”. https://www.heartandstroke.ca/what-we-do/our-impact/fighting-for-prevention. Accessed on September 14, 2025.
- World Health Organization. “Cardiovascular diseases (CVDs)”. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds). Accessed on September 14, 2025.
- R.P. Gale. “Risk Factors for Cancer”. Merck Manual, September 2024. https://www.merckmanuals.com/en-ca/home/cancer/overview-of-cancer/risk-factors-for-cancer. Accessed on September 14, 2025
- Statistics Canada. “Top 10 leading causes of death”. November 2023. https://www150.statcan.gc.ca/n1/daily-quotidien/231127/t001b-eng.htm. Accessed on September 15, 2025.
- INSERM. “Pour s’éviter un bide – C’est quoi le syndrome métabolique?” March 2022. https://www.inserm.fr/c-est-quoi/pour-seviter-un-bide-cest-quoi-le-syndrome-metabolique/. Accessed on September 15, 2025.
- Anhet France. “Glossaire de l’Hypercholestérolémie Familiale”. https://www.anhet.fr/glossaire. Accessed on September 15, 2025.
- Merck Manual. “Peripheral Arterial Disease”. April 2025. https://www.merckmanuals.com/en-ca/home/quick-facts-heart-and-blood-vessel-disorders/peripheral-arterial-disease/peripheral-arterial-disease. Accessed on September 15, 2025.
